HEIDELBERG, Germany – Researchers at the Max Planck Institute for Medical Research have developed a paper-based biosensor that can measure concentrations of metabolites such as phenylalanine in small blood samples within minutes. The researchers said the biosensor could become an important tool for diagnosing and managing various diseases. “Diseases or injuries can result in dramatic changes in metabolite blood levels,” said Kai Johnsson, lead researcher, in a statement. “It is therefore essential to have some means of regularly monitoring phenylalanine levels in blood. We introduced a fundamentally new mechanism to measure metabolites for blood analysis.” The biosensor was validated with patient samples obtained from the Heidelberg and Lausanne University Hospitals. “We are now looking for ways to further automatize and simplify the test,” said Johnsson.
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